J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.24.00670. Online ahead of print.

ABSTRACT

BACKGROUND: Musculoskeletal abnormalities have been reported among female professional ballet performers due, in part, to intrinsic predispositions related to joint and/or connective tissue laxity and extrinsic effectors such as reduced energy availability, low body mass, and high training volumes that may increase the risk of developing idiopathic scoliosis (IS). The purpose of this investigation was to characterize IS prevalence in this population. We hypothesized that there would be elevated prevalence in female performers and that those with IS would exhibit reduced bone mineral density (BMD), body mass, fat mass, and lean mass.

METHODS: A retrospective analysis of whole-body anteroposterior radiographs was performed on 98 professional ballet dancers (49 male performers [mean age, 25 ± 6 years] and 49 female performers [mean age, 27 ± 5 years]) from a single company. Body composition and BMD were assessed via dual x-ray absorptiometry. The criterion for IS was defined as a Cobb angle of >10°. The frequency of IS was plotted against general-population norms. A t test was used to compare demographic characteristics, anthropometrics, and BMD between performers with and without IS and to compare the Cobb angles between sexes. A Fisher exact test was used to compare the IS prevalence between sexes. The Type-I error was set at α = 0.05.

RESULTS: Compared with male performers, female performers had greater spinal asymmetry (mean Cobb angle, 7.98° [95% confidence interval (CI) width, 1.76°] for men and 4.02° [95% CI width, 1.00°] for women; p = 0.027). The prevalence of IS among male performers (3 [6.12%] of 49) was comparable with the general-population norms (0.31% to 5.60%). Women had an elevated prevalence of IS compared with men (10 [20.41%] of 49; p = 0.037) and with general-population norms (0.65% to 8.90%). Among women, performers with IS were observed to have a reduced percentage of body fat (p = 0.021) and reduced fat mass (p = 0.040) compared with performers without IS.

CONCLUSIONS: Female professional ballet performers demonstrate a heightened prevalence of IS that, in addition to intrinsic predisposition, is associated with modifiable factors such as reduced fat mass commonly associated with reduced energy availability known to impact musculoskeletal health in athletes. Future investigations should seek to determine the prevalence of IS in other young female athlete populations commonly exposed to high degrees of activity and reduced energy availability.

LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40273227 | DOI:10.2106/JBJS.24.00670

J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.24.00857. Online ahead of print.

ABSTRACT

BACKGROUND: At our institution, surgeons were observing cases of failed total knee arthroplasties (TKAs) with surface delamination of the tibial insert fabricated by direct compression molding. The increase in unexpected failure led us to investigate the prevalence of delamination and its causes through the use of retrieval analysis and reviews of clinical, demographic, and radiographic data.

METHODS: Between 2000 and 2019, a total of 519 Exactech Optetrak posterior-stabilized direct-compression-molded polyethylene inserts had been retrieved. To determine prevalence, we utilized institutional usage data, manufacturer sales to our institution, and hospital records to determine the delamination rate. Eighty-six retrieved specimens (16 with delamination) were assessed for oxidation with use of infrared spectroscopy.

RESULTS: Sixty-four (12%) of the 519 inserts had delamination. The delamination rate was 0.36% across the 20-year period. Osteolysis was the reason for revision in 25% of delaminated cases, compared with 4% of non-delaminated cases. The mean oxidation index of the delaminated inserts was 2.67 ± 1.4 (range, 1.2 to 6.6). Delamination was not associated with surgical factors (cement viscosity and tibial insert thickness) or processes associated with manufacturing and implantation of the inserts into the patients (implantation year, shelf life, and packaging and sterilization dates).

CONCLUSIONS: The lack of causative factors for the increase in delamination was perplexing. In 2021, following the completion of our study, the manufacturer determined that since 2004, polyethylene inserts were packaged in "non-conforming" vacuum bags that were missing a secondary barrier layer intended to markedly lessen oxygen permeation. The use of non-conforming bags apparently increased the risk of premature oxidation, delamination, and associated osteolysis.

LEVEL OF EVIDENCE: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

PMID:40273225 | DOI:10.2106/JBJS.24.00857

J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.24.01118. Online ahead of print.

ABSTRACT

BACKGROUND: Sarcopenia increases postoperative complication and mortality rates in elderly patients. Although measurement of the psoas muscle area on computed tomography (CT) scans is traditionally used to diagnose sarcopenia, CT is not routine in orthopaedic practice and causes unnecessary radiation exposure. EOS, a low-dose full-body imaging modality, captures musculoskeletal structures in an upright position, offering an alternative for sarcopenia diagnosis.

METHODS: Patients ≥18 years of age were included in this retrospective study if they had undergone non-contrast CT spine and EOS imaging between May 2022 and May 2024. Psoas muscle measurements at L3 and L4 were made using non-contrast CT scans, while thigh muscle measurements were obtained with EOS imaging. Inter- and intra-rater reliabilities were assessed using intraclass correlation coefficients (ICCs). Predicted probabilities for L4-psoas sarcopenia were determined through logistic regression, controlling for demographic covariates and validated with an 80% to 20% train-validate split. Sarcopenia cutoffs for anteroposterior (AP) thigh thickness and lateral (LAT) quadriceps thickness were determined with use of the Youden index.

RESULTS: Sarcopenia was identified in 23.1% of 134 patients (85 female and 49 male; 121 White, 7 Black, and 6 Hispanic) on the basis of L4-psoas muscle index thresholds. EOS and CT measurements showed excellent ICCs (≥0.90). Multivariable regressions identified AP thigh thickness and LAT quadriceps thickness as significant predictors of psoas area and L4-psoas sarcopenia. The area under the receiver operating characteristic curve for identifying L4-psoas sarcopenia was 0.85 for AP thigh thickness and 0.77 for LAT quadriceps thickness. Cutoffs were 12.47 cm (males) and 10.68 cm (females) for AP thigh thickness, and 3.23 cm (males) and 2.20 cm (females) for LAT quadriceps thickness. In the validation cohort of 27 patients, the AP thigh thickness model showed 0.94 sensitivity and 0.89 specificity, while the LAT quadriceps thickness model showed 0.70 sensitivity and 1.00 specificity. Applying these cutoffs to the entire data set showed that 66.7% of males and 75.0% of females with measurements below both cutoffs had sarcopenia.

CONCLUSIONS: EOS is a reliable alternative to CT for muscle mass assessment and sarcopenia diagnosis. EOS may be a valuable tool for assessing sarcopenia without a CT scan, as thigh muscle measurements via EOS correlate well with CT-derived psoas measurements. This imaging modality aids in early sarcopenia diagnosis, potentially enhancing preoperative planning and reducing radiation exposure, unnecessary costs, and resource utilization.

LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40273215 | DOI:10.2106/JBJS.24.01118

J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.24.01212. Online ahead of print.

ABSTRACT

BACKGROUND: Although it is well established that the type of organism can be a risk factor for failure in patients with periprosthetic joint infection (PJI), no study to date has examined the impact of the number of positive cultures on treatment outcomes in patients undergoing 2-stage exchange. The purpose of this multicenter study was to determine the prognostic utility of multiple positive cultures at resection as a predictor of failure following reimplantation.

METHODS: This retrospective multicenter study identified 437 patients with chronic knee PJI who had undergone 2-stage exchange arthroplasty with a minimum of 1 year of follow-up following reimplantation. PJI was defined with use of the 2013 Musculoskeletal Infection Society (MSIS) criteria. Patients with culture-negative PJI were excluded (n = 138). Treatment failure was defined as either any reoperation for infection or PJI-related mortality. Multivariable regression controlling for risk factors for failure after a 2-stage arthroplasty was performed to determine whether ≥2 positive intraoperative cultures at resection can predict outcomes following reimplantation when compared with a single positive culture.

RESULTS: Two hundred and ninety-nine patients were included. At a mean follow-up of 6.2 ± 2.6 years, 48 patients (16.1%) experienced failure. Patients who had a failure were more likely to have had a longer interstage interval (p = 0.038) and were also more likely to have had ≥2 positive cultures at the time of resection arthroplasty (95.8% versus 75.3%; p = 0.001). On regression analysis, ≥2 positive cultures at resection was the only variable that was identified as a risk factor for failure following reimplantation in both the univariate (odds ratio [OR], 7.55 [95% CI, 2.24 to 47.0]; p = 0.006) and multivariable models (OR, 8.12 [95% CI, 2.31 to 51.9]; p = 0.005).

CONCLUSIONS: This is the first study to examine the impact of the number of positive cultures on outcomes in patients with PJI. We found that the presence of ≥2 positive cultures at resection was an indicator of a poor prognosis and resulted in a greater than eightfold increase in the risk of treatment failure in patients undergoing a 2-stage exchange.

LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40273213 | DOI:10.2106/JBJS.24.01212

J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.23.01391. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of this study was to determine the risk factors associated with deep vein thrombosis (DVT) or pulmonary embolism (PE) within 30 days after multilevel adult spinal deformity (ASD) surgery and to develop risk prediction models.

METHODS: A retrospective observational study was conducted using the American College of Surgeons National Surgical Quality Improvement Program database from 2010 to 2019. Current Procedural Terminology (CPT) codes 22843 and 22844 were used to query the database and to identify patients who underwent surgical correction of ASD with ≥7 levels of posterior instrumentation. The primary outcomes were the incidences of, and risk factors for, postoperative DVT and PE. Multiple logistic regression was utilized to identify variables associated with an elevated risk of DVT or PE within 30 days after surgery and to develop prediction models for assessing risk.

RESULTS: A total of 7,445 patients (56% female; 73% Caucasian; mean age, 61 years) met the inclusion criteria. Postoperatively, the rate of any venous thromboembolism (VTE; i.e., DVT or PE) was 3.4% (254 patients), the rate of DVT was 2.0% (151 patients), and the rate of PE was 1.7% (127 patients). The following independent predictors of any VTE were identified: weight (odds ratio [OR], 1.054; 95% confidence interval [CI]: 1.027 to 1.081), age per decade of life (OR, 1.106; 95% CI: 1.012 to 1.209), body mass index (BMI; OR, 1.032; 95% CI: 1.015 to 1.049), medicated hypertension (OR, 1.523; 95% CI: 1.168 to 1.987), chronic corticosteroid use (OR, 2.654; 95% CI: 1.848 to 3.812), American Society of Anesthesiologists (ASA) class (OR, 1.768; 95% CI: 1.426 to 2.192), and total operative time (OR, 1.002; 95% CI: 1.002 to 1.003) (p < 0.05 for all). When incorporated into a single model, total operative time, BMI, ASA class, and chronic corticosteroid use were associated with VTE risk.

CONCLUSIONS: Four major risk factors were identified as being associated with postoperative VTE risk in patients undergoing surgery for ASD. Corticosteroid use for a chronic medical condition was the strongest predictor of VTE risk, followed by ASA class, BMI, and operative time. Knowledge of these risk factors can aid in preoperative risk assessment, informed consent, and medical decision-making, such as in determining the clinical thresholds for VTE testing and chemoprophylaxis.

LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40273208 | DOI:10.2106/JBJS.23.01391

J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.24.01265. Online ahead of print.

ABSTRACT

BACKGROUND: Osseous reconstructive surgery for hip displacement in children with cerebral palsy (CP) consists of proximal femoral reorientation by varus derotational osteotomy (VDRO) combined with pelvic osteotomy when indicated. The rate of recurrent hip instability after the index surgery can be as high as 77%. We evaluated the association between femoral diaphyseal medialization at the VDRO site and recurrent instability. We hypothesized that medialization may modify the hip joint reaction force (HJRF), reducing the femoral remodeling that leads to recurrent coxa valga and instability.

METHODS: A retrospective evaluation of the clinical and radiographic records of 140 patients (280 hips) with CP, Gross Motor Function Classification System (GMFCS) Level IV or V, who had been treated with bilateral VDRO as the index surgery for hip displacement between 1998 and 2012 (mean follow-up, 11.3 years) was conducted. Radiographic measurement of medialization was performed using the medialization index (MeI) preoperatively, at 6 weeks and 12 months postoperatively, and at skeletal maturity. Recurrent instability was defined as the need for revision surgery before skeletal maturity or a final migration percentage (MP) of >40%.The influence of the MeI was determined by Poisson regression with multiple variances. The inter- and intra-observer reliability of the MeI, measured by 4 different observers, was assessed using the Cohen d test.

RESULTS: Groups with and without relapse were comparable preoperatively regarding femoral and acetabular parameters. The baseline MP was higher in the relapse group (p < 0.001). The MeI at 6 weeks postoperatively was significantly lower in the relapse group (p = 0.004, relative risk [RR] = 0.07, 95% confidence interval [CI] = 0.01 to 0.42) than in the no-relapse group in multivariable analysis. The MeI showed good inter- and intra-observer reliability, with a Cohen d of <0.5.

CONCLUSIONS: Patients with greater medialization had lower rates of recurrent hip instability at long-term follow-up. The MeI proved to be reliable as a radiographic measurement, and medialization did not increase mechanical instability.

LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

PMID:40273207 | DOI:10.2106/JBJS.24.01265

J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.25.00101. Online ahead of print.

NO ABSTRACT

PMID:40273198 | DOI:10.2106/JBJS.25.00101

Injury. 2025 Apr 17:112306. doi: 10.1016/j.injury.2025.112306. Online ahead of print.

ABSTRACT

BACKGROUND: The popularity of electric bicycles (E-bikes) in The Netherlands has surged in recent years. Simultaneously, bicycle-related traffic injuries in The Netherlands have reached record levels. Given the significant societal and individual impact of traumatic brain injury (TBI) we investigated the relationship between E-bike usage and the occurrence of severe TBI.

METHODS: All bicycle crash victims aged twelve years and older admitted to the Isala Hospital from 1 January 2018 to 31 December 2022, were included from the National Trauma Registry. Data on bicycle type, anticoagulants, alcohol intoxication, and helmet use, was obtained from the hospitals' electronic patient record. The primary outcome variable was severe TBI verified on CT- or MRI-imaging. The secondary outcome variable was a skull fracture verified on X-ray or CT-imaging. Adjusted odds ratios (ORs) and 95 %-confidence intervals (CIs) were calculated using multivariable binary logistic regression analyses, adjusting for the risk factors alcohol intoxication, anticoagulant use, not wearing a helmet, health status before the accident, age and gender.

RESULTS: From 1 January 2018 to 31 December 2022, a total of 1878 patients were admitted following a bicycle crash. This group consisted of 1359 (73.4 %) regular cyclists and 519 (27.6 %) E-bikers. Multivariable regression analyses resulted in an OR of 1.64 (CI 1.20-2.22) for severe TBI and an OR of 1.50 (CI 1.08-2.08) for skull fractures.

CONCLUSION: In our study sample, E-bike usage was found to be an independent predictor for severe traumatic brain injury and skull fractures following a bicycle crash.

PMID:40268590 | DOI:10.1016/j.injury.2025.112306

Injury. 2025 Apr 15;56(6):112345. doi: 10.1016/j.injury.2025.112345. Online ahead of print.

ABSTRACT

INTRODUCTION: Describing surgical wounds accurately poses challenges due to the diverse terminology used for complications. Existing evaluation methods do not cater specifically to surgical wounds from post-ankle fracture surgery with osteosynthesis. Given the unique anatomical challenges and treatment considerations (limited tissue coverage and blood supply as well as the surgical treatment with osteosynthesis), a targeted wound score is essential for ensuring consistent evaluation and high-quality care and thereby optimizing patient outcomes and satisfaction. The study aimed to develop a wound score specifically for evaluating surgical wounds following ankle fracture surgery.

METHOD: Development of the Wound after Osteosynthesis Kolding score (WOK) proceeded through three phases: 1) identifying WOK domains, 2) developing item and response options, and 3) pilot testing the WOK score.

RESULTS: Five domains were identified: erythema, swelling, dehiscence, exudate and warmth. Response options were derived from literature and clinical insights. Content validity was assessed with an S-CVI/Ave of 0.93 for nurses and 0.82 for orthopedic surgeons. Orthopedic surgeons perceived erythema and warmth as less relevant, while nurses considered all five domains to be fairly or very relevant. High agreement between scores was found, but varying kappa scores were observed when assessing intra-rater reliability. Inter-rater reliability was acceptable across all domains (κ = 0.44 to 1.00). Warmth was omitted from the final WOK score due to low content validity among orthopedic surgeons and poor inter-rater reliability. Additionally, assessing warmth in a clinical setting was challenging because ankle brace stabilization affects overall skin humidity and warmth.

CONCLUSIONS: The Wound after Osteosynthesis Kolding score (WOK) has proven to be a content-valid and reliable tool for assessing minor complications in surgical wounds following ankle fracture surgery.

PMID:40267859 | DOI:10.1016/j.injury.2025.112345

Injury. 2025 Apr 17;56(6):112354. doi: 10.1016/j.injury.2025.112354. Online ahead of print.

ABSTRACT

History - A 38yo man was injured in a rugby match. He suffered an isolated, Achilles tendon rupture. He immediately went to his local emergency department. He was keen on the best treatment so that he could get back into playing rugby with his community team. Past Medical History and Social History - He was a married man and lived with his wife. He was a nonsmoker. He had no medical problems that he saw a physician about. He worked as an executive with an oil company and was also involved in many sports year-round. He had had surgery for previous sports related broken bones with no complications. He had no allergies and took no medications. He was a regular beer drinker after sports matches.

PMID:40267858 | DOI:10.1016/j.injury.2025.112354

Injury. 2025 Apr 12;56(6):112338. doi: 10.1016/j.injury.2025.112338. Online ahead of print.

ABSTRACT

BACKGROUND: This study aimed to investigate the outcomes of fasciotomy, including infection, amputation, and complications, in patients with crush injuries from the 2023 Turkey-Syria earthquake.

MATERIAL AND METHODS: Out of 210 patients presenting from the earthquake zone, 46 patients (23 male-23 female, mean age: 21 years) who underwent 52 extremity fasciotomies were included. Data collected included infection rates, need for grafts/flaps, amputation rates, creatinine, CK levels, need for dialysis, and neurologic injuries. Early fasciotomy was defined as ≤12 h and late as >12 h after the earthquake. Patients were categorized by fasciotomy timing and location (earthquake-zone or university hospital). Time to first debridement was also evaluated.

RESULTS: The median time to fasciotomy was 24 h (2-97 h, (IQR 12.5-65)). Fasciotomies performed in the earthquake zone had a higher infection rate (68 % vs. 25 %, p = 0.061), though this difference was not statistically significant, likely due to the small sample size. There was no significant difference in infection rates between patients who underwent early fasciotomy (8/13, 62 %) and those who underwent late fasciotomy (20/33, 61 %) (p = 1.0).Amputation was required in 7/46 patients (15 %), with 1/13 patient (8 %) in the early fasciotomy group and 6/33 patients (18 %) in the late fasciotomy group (p = 0.698). Skin grafting was performed for wound closure in 19 patients (42 %). In patients undergoing early fasciotomy, 75 % (9/12) required skin grafts for wound closure, whereas the rate in the late fasciotomy group was significantly lower at 30 % (10/33) (p = 0.019). The mean time to first debridement was significantly higher in infected patients [65.5 (SD 11.8) vs 57.8 (SD 11.4 h), p = 0034]. For wounds that required skin grafts, the average duration between the fasciotomy and initial debridement was significantly higher (68.5 vs 54 h), p = 0.001.

CONCLUSION: Fasciotomies performed in earthquake zones had higher infection rates compared to hospitals, though not statistically significant. Infections with potentially multi-drug resistant bacterias may increase the risk of complications like amputations. Timely debridement and efficient patient transfer remain essential to minimizing risks and improving outcomes.

PMID:40267857 | DOI:10.1016/j.injury.2025.112338

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06535-y. Online ahead of print.

NO ABSTRACT

PMID:40266313 | DOI:10.1007/s00264-025-06535-y

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06525-0. Online ahead of print.

ABSTRACT

PURPOSE: To assess long term survivorship, patient reported (PROMs) and radiological outcomes, and rate of adverse events and hardware removal after lateral closing wedge high tibial osteotomy (CWHTO) for the treatment of medial knee osteoarthritis (OA) and varus malalignment.

METHODS: Retrospective analysis of patients who underwent isolated CWHTO for medial OA in varus knee between 2009 and 2019 at the same institution was performed. Surgical failure was defined as conversion to total knee arthroplasty (TKA) or need for osteotomy revision procedure for varus recurrence, while clinical failure was defined by a Lysholm score under 65 points. Lysholm score, Visual Analogue Scale for pain (VAS), and patients' satisfaction with the treatment were evaluated. Radiographic parameters assessed included OA degree with the Kellgren Lawrence scale (KL), hip-knee-ankle angle (HKA), medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), joint line convergence angle (JLCA), and posterior tibial slope (PTS). Adverse events and rate of hardware removal procedures were recorded through follow up visits and clinical records. Survival analysis was conducted through Kaplan-Meier method with surgical and clinical failure as endpoints.

RESULTS: 70 knees (mean age at surgery 43.3 years) were included in the survivorship analysis at a mean follow up of 11.6 ± 3.4 years. A failure rate of 12.85% (9/70) was recorded during the follow up period, with a survivorship of 92% and 75% at ten and 15 years of follow up, respectively. Mean Lysholm score and VAS at follow up were above the PASS threshold reported in literature. The 75.7% of patients were satisfied with the treatment. Radiological follow up indicated a residual mechanical varus of 2.1°, a decrease of 0.7° of intra articular deformity (JLCA), no change in PTS nor in KL index. The adverse events rate recorded was 5.7% (4/70). In nine knees (14.7%) among the patients survived from surgical failure a subsequent hardware removal procedure was performed.

CONCLUSION: CWHTO represents a safe procedure, which resulted in high survivorship (92% and 75% at ten and 15 years follow up, respectively), with satisfactory PROMs and radiological outcomes at long term follow up in patients affected by medial OA and varus malalignment.

LEVEL OF EVIDENCE: 5, Case Series.

PMID:40266312 | DOI:10.1007/s00264-025-06525-0

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06542-z. Online ahead of print.

ABSTRACT

PURPOSE: To evaluate the efficacy of acellular hyaluronic acid matrix scaffold, BMAC, and autologous bone graft in providing biomechanical support and optimal microenvironment for OLTs treatment.

METHODS: A retrospective analysis of 81 ankles from 80 patients treated between 2018 and 2021 was conducted. The inclusion criteria included patients who underwent surgery for osteochondral lesions of the talus (OLTs) and received acellular hyaluronic acid matrix scaffold, bone marrow aspirate concentrate (BMAC) fibrin glue, and autologous bone graft. The exclusion criteria included prior ankle surgery, concurrent lateral instability surgery, malignancy, metabolic bone disease, or related medication. Clinical outcomes were assessed with FAOS, VAS, and SF-36 at a minimum of two years postoperatively. MRI findings were evaluated preoperatively, at six months, and 24 months postoperatively via MOCART. Subgroups were formed on the basis of age (< 45 vs. ≥45), BMI, and full weight bearing mobilization (FWBM) timing (4, 5, 6, or > 6 weeks).

RESULTS: Postoperative FAOS and SF-36 scores significantly improved (p = 0.000), whereas VAS scores decreased (p = 0.001). Early FWBM (4th week) was associated with superior FAOS, SF-36, and MOCART scores at 24 months (p = 0.039). Underweight and healthy individuals exhibited lower VAS (p = 0.001) and higher SF-36 scores (p = 0.000) at three months, alongside higher MOCART scores at 24 months compared to overweight patients (p = 0.039).

CONCLUSIONS: This study highlights the importance of a tailored approach to optimize the microenvironment and biomechanical support in OLTs treatment. Further research is required to refine therapeutic strategies.

PMID:40266311 | DOI:10.1007/s00264-025-06542-z

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06523-2. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to evaluate the early clinical and radiological outcomes of robot assisted total knee arthroplasty, and to determine the efficiency and safety of its bone resection and implant positioning of the novel robot system.

METHODS: 144 patients who underwent primary TKA were enrolled in this prospective, multicenter RCT conducted in three hospitals. five patients were lost to follow-up at six weeks after surgery. Therefore, 139 patients (73 in the RA TKA group and 66 in the CI TKA group) remained in the final analysis. The primary outcome was the rate of patients whose postoperative alignment was less than 3° deviated from the planned evaluated by full-length weight-bearing X-rays of the lower limb at 12 weeks postoperatively. Secondary outcomes included coronal and sagittal alignment of the components, operation times, blood loss, 12-week range of motion(ROM), 12-week postoperative functional outcomes and satisfaction evaluated by the American Knee Society Score (KSS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and adverse events (AEs).

RESULTS: At 12 weeks postoperatively, we found the rate of radiographic inliers was significantly higher in the RA TKA group (90.4% vs. 59.1%; p < 0.05). The difference between planned and postoperative frontal femoral component (FFC) angle, frontal tibia component (FTC) angle and lateral femoral component (LFC) angle are significantly smaller in the RA TKA group (p < 0.05). The operation time was significantly longer in the RA TKA group than in the CI TKA group (133.01 vs. 92.33 min; p < 0.05). There was no significant difference in blood loss, 12-week ROM, 12-week postoperative functional outcomes and satisfaction evaluated by KSS and WOMAC scores. There were no AEs or SAEs that were determined to be "related" to the robotic system.

CONCLUSION: The novel robot assisted TKA is safe and more precise in bone resection and implant positioning as demonstrated in this trial.

PMID:40266310 | DOI:10.1007/s00264-025-06523-2

Injury. 2025 Apr 14:112344. doi: 10.1016/j.injury.2025.112344. Online ahead of print.

ABSTRACT

INTRODUCTION: Adverse Childhood Experiences (ACEs), such as violence exposure, are linked with numerous long-term health consequences. Adult firearm and other injury survivors presenting to level I trauma centers frequently report having youth family members exposed to firearm violence and other traumatic life events. Few investigations have examined the demographic and familial characteristics, or cumulative trauma burden of exposed family members.

METHODS: The investigation was a secondary analysis of data collected as part of a 25-site national US level I trauma center randomized clinical trial (N = 635). Baseline characteristics of firearm injury survivors (n = 128) versus all other injury survivors (n = 507) were compared, including number of children, pre-injury trauma history, and post-admission recurrent traumatic and stressful life events. Analyses were conducted on baseline characteristics of firearm injury survivors, including trauma history, and compared to non-firearm injury survivors. For injury survivors with children, mixed model regression was used to assess whether firearm injury was independently associated with an increased risk of childhood injury leading to hospitalization over the course of the year after the index parental injury admission.

RESULTS: There were few demographic and clinical differences between firearm and non-firearm injury survivors. Approximately 70% of adult injury survivors had at least one child. Over 10% of adult injury survivors had a child hospitalized in the year after the index admission; firearm injury survivors were no more likely than all other injury survivors to have a child hospitalized after the index admission. For injury survivors with children, mixed model regression analyses revealed a significant association between pre-injury childhood exposure to life-threating illness/injury and child injury hospitalization in the year after the index parental injury admission (Relative Risk = 1.92, 95% Confidence Interval = 1.08, 3.42).

CONCLUSIONS: Over 10% of adult injury survivors reported that their children were hospitalized for an injury in the year after an index injury admission. Prehospital childhood illness or injury admission was significantly associated with childhood injury hospitalization in the year after parental injury. Trauma centers could be harnessed as a public health point-of-contact for screening, intervention, and referral of ACEs, such as childhood injury.

PMID:40263031 | DOI:10.1016/j.injury.2025.112344

Injury. 2025 Apr 8;56(6):112315. doi: 10.1016/j.injury.2025.112315. Online ahead of print.

ABSTRACT

AIMS: In an increasingly frail population, simultaneous "fix and replace" surgery (fixation of the acetabulum to accommodate a press fit cup and total hip arthroplasty (THA)) is a novel alternative to open reduction and internal fixation (ORIF) alone in the management of acetabular fractures. We aimed to determine whether patients managed with "fix and replace" have comparable survivorship to those undergoing staged THA following previous open reduction and internal fixation for acetabular fracture.

METHODS: All Patients with acetabular fractures surgically managed within our Tertiary centre over a five year period (01/01/2018-30/05/2023) were identified. Thirty-four patients underwent simultaneous "fix and replace" surgery and 133 underwent acetabular ORIF alone. Twenty-one of these patients required staged THA (6 %).

RESULTS: Follow up mean was 2.7 years (SD ±1.7) for 'fix and replace' versus 3.3 years (SD ± 1.5) for staged THA. There was no statistically significant difference between the two groups with regards to BMI or sex. The fix and replace group were older (p = 0.001), had higher American Society of Anesthesiologists (ASA) grade (p = 0.006) and Charlson Comorbidity Index (CCI) (p = 0.027), respectively. High energy mechanism of injury accounted for 56 % of the "fix and replace" group compared to 48 % in the ORIF to THA. 74 % of 'fix and replace' were associated/complex fractures (LeTournel) compared to 53 % of staged THA. Mean wait to surgery was 3 days in the 'fix and replace' group compared to 186 days from listing to operation in the staged THA group. Survival analysis demonstrated acceptable results for both groups with greater than 85 % survival at 2 years and no statistical significantly worse survivorship in the 'fix and replace' group (p = 0.13). Complications were comparable in both groups (41 % versus 43 %, p = 0.58).

CONCLUSIONS: 'Fix and replace' is a good option for the elderly, co-morbid patient. It enables early weight bearing and has acceptable survivorship compared to staged THA following acetabular ORIF.

PMID:40262410 | DOI:10.1016/j.injury.2025.112315

J Bone Joint Surg Am. 2025 Apr 22. doi: 10.2106/JBJS.24.00248. Online ahead of print.

ABSTRACT

BACKGROUND: We previously established a small animal model of femoral head-neck cam-type hip deformity by inducing physeal injury in immature rabbits. We investigated whether this induced deformity led to hip osteoarthritis (OA) within 4 months.

METHODS: Six-week-old immature New Zealand White rabbits underwent surgery to induce physeal injury in the right femoral head, causing growth arrest and secondary head-neck deformity. Animals were divided into early-pre-OA (4 weeks) and late-OA (16 weeks) groups. Left hips served as (nonsurgical) controls. Radiographs were made to visualize deformities and OA progression. The Beck classification was used to assess macroscopic cartilage damage and OA on the acetabulum and femoral head. Micro-computed tomography (CT), histological scoring, and gene expression were used to evaluate OA progression. The Wilcoxon signed-rank test was used for group comparisons. Significance was set at p < 0.05.

RESULTS: At 16 weeks, the injured hips showed radiographic evidence of joint space narrowing and a higher OA grade than the control hips (p = 0.0002). Micro-CT confirmed degenerative OA changes and a higher femoral head bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) in the injured hips than in the control hips (BV/TV: p = 0.0001, Tb.Th: p = 0.0007). Macroscopically, the injured hips exhibited a greater prevalence and severity of chondral lesions at 4 weeks (83.3%, p = 0.015) and 16 weeks (100.0%, p = 0.002) post-injury compared with the control hips (0%), with worsening over time (4 versus 16 weeks: p = 0.016). The Osteoarthritis Research Society International (OARSI) score and synovitis score increased from 4 to 16 weeks post-injury. Compared with the control hips, the injured hips showed decreased Col2 expression and increased Col10 and MMP13 expression at 16 weeks post-injury (p = 0.062, p = 0.016, p = 0.041, respectively), confirming catabolism and OA progression.

CONCLUSIONS: To our knowledge, we have created the first small animal model of hip OA secondary to experimentally induced head-neck deformity. In this model, the deformity resulted in hip OA at 16 weeks post-injury.

CLINICAL RELEVANCE: This model can be used to test future interventional therapies and study mechanisms of femoroacetabular impingement-mediated hip OA.

PMID:40261969 | DOI:10.2106/JBJS.24.00248

Int Orthop. 2025 Apr 22. doi: 10.1007/s00264-025-06543-y. Online ahead of print.

NO ABSTRACT

PMID:40261340 | DOI:10.1007/s00264-025-06543-y

Int Orthop. 2025 Apr 22. doi: 10.1007/s00264-025-06538-9. Online ahead of print.

NO ABSTRACT

PMID:40261339 | DOI:10.1007/s00264-025-06538-9