Injury. 2026 May 7;57(7):113348. doi: 10.1016/j.injury.2026.113348. Online ahead of print.
ABSTRACT
BACKGROUND: Fragility fractures represent a major public health concern in the aging population, contributing substantially to morbidity, functional decline, and mortality. Although hip fractures are widely recognized for their high early mortality risk, less is known about the comparative one-year mortality associated with first-time long bone fractures at other anatomical sites. This study evaluates one-year all-cause mortality across multiple fracture types in older adults using a large, multicenter research network.
METHODS: We performed a retrospective cohort study using the TriNetX US Collaborative Network, identifying patients ≥ 65 years with a first-time long bone fracture between 2004 and 2024. Fracture types included hip, pertrochanteric, subtrochanteric, distal femur, proximal tibia, distal tibia, proximal humerus, and distal humerus fractures. Patients with pathologic, metastatic, or multiple fractures were excluded. A non-fracture cohort of age-matched older adults served as the comparison group. The primary outcome was one-year all-cause mortality. Propensity score matching (1:1) was used to balance demographics. Relative risks (RR) with 95% confidence intervals (CIs) and Kaplan-Meier survival analyses were performed.
RESULTS: A total of 165,017 fracture patients and 4.55 million non-fracture controls were identified; 162,469 patients remained after matching per cohort. All fracture types were associated with significantly increased one-year mortality compared with matched controls (2.77%). Hip fractures demonstrated the highest risk (27.9%; RR 4.86, 95% CI 4.65-5.08), followed by pertrochanteric (23.9%; RR 4.14) and subtrochanteric fractures (15.2%; RR 2.98). Distal femur fractures carried a 9.4% mortality risk (RR 2.71). Mortality for distal humerus, distal tibia, proximal tibia, and proximal humerus fractures ranged from 5.6 to 7.1% (RR 1.63-1.97).
CONCLUSION: First-time long bone fractures in older adults are associated with significantly elevated one-year mortality, with hip and proximal femur fractures conferring the greatest risk. These findings underscore the need for early risk stratification, targeted postoperative care, fall-prevention strategies, and multidisciplinary management to reduce fracture-related mortality in the geriatric population.
PMID:42107204 | DOI:10.1016/j.injury.2026.113348