Int Orthop. 2025 Apr 8. doi: 10.1007/s00264-025-06524-1. Online ahead of print.

ABSTRACT

We study Hernigou P's paper "Is synovectomy still of benefit today in total knee arthroplasty with rheumatoid arthritis?" It highlights the need for further research and progress in this field. Future studies should address limitations like small sample sizes, inadequate patient stratification, lack of quantifiable metrics for synovectomy extent, and limited early postoperative analyses to provide stronger evidence for clinical practice.

PMID:40198386 | DOI:10.1007/s00264-025-06524-1

Int Orthop. 2025 Apr 8. doi: 10.1007/s00264-025-06522-3. Online ahead of print.

NO ABSTRACT

PMID:40198385 | DOI:10.1007/s00264-025-06522-3

Injury. 2025 Apr 5;56(6):112327. doi: 10.1016/j.injury.2025.112327. Online ahead of print.

ABSTRACT

BACKGROUND: Patients undergoing surgery are at significant risk of developing pressure injuries due to immobility and fixed positioning on the operating table, particularly during lengthy procedures. Therefore, implementing effective prevention strategies for pressure injuries should begin as early as the surgical phase. This study aims to compare the two methods of curvilinear position and micromovement in preventing pressure injuries among patients undergoing general surgery in the supine position.

METHOD: This was a double-blind, prospective, randomized, controlled trial conducted from October 2024 to January 2025. The study included a sample size of 120 patients randomly divided into three groups: control (n = 40), micromovement (n = 40), and curvilinear (n = 40). Skin assessments were conducted using the National Pressure Ulcer Scale immediately after surgery and again one day later.

RESULTS: A total of 114 patients were included in the analysis: 39 in the control group, 38 in the micromovement group, and 37 in the curvilinear group. A significant difference was found between the three groups regarding the incidence of pressure injuries (p < 0.05). However, there was no considerable difference regarding the location and stage of the pressure injury between groups (p > 0.05).

CONCLUSION: Micromovement and curvilinear supine position can significantly reduce the incidence of intraoperative acquired pressure injuries. Therefore, it is recommended that these methods be utilized as an effective intervention by the surgical team, especially for high-risk patients and those undergoing prolonged surgeries.

PMID:40194328 | DOI:10.1016/j.injury.2025.112327

Int Orthop. 2025 Apr 7. doi: 10.1007/s00264-025-06507-2. Online ahead of print.

ABSTRACT

BACKGROUND: Modular dual mobility (MDM) cups are constituted by a cobalt-chromium (CoCr) liner inserted into a standard acetabular shell, allowing for intra-operative decision and supplementary screw fixation of the acetabular component. MDM could face mechanical issues and biological issues, with the associated risk of elevated blood metal ions levels and adverse local tissue reactions (ALTRs).

MATERIALS AND METHODS: A systematic review of the literature on minimum five years outcomes of modular dual mobility in primary total hip arthroplasty (THA) was performed on PubMed, Cochrane, and Google Scholar databases, in adherence with PRISMA guidelines. Risk of bias in each study was assessed through the JBI checklist for case series.

RESULTS: A total of 381 primary THAs with MDM acetabular cup were performed. At minimum five years follow-up, mean revision rate was 2.3% and implant survivorship was 98.2%. No MDM acetabular construct was revised specifically due to liner mechanical failure, neck-rim impingement, or ALTRs. No intraprosthetic dislocation or iliopsoas tendinitis was observed. No cases of THA dislocation were reported. Mean serum metal ion levels were observed to be within laboratory reference ranges. Greater-than-normal values of serum Co were observed in 9.4% of cases, while greater-than-normal values of serum Cr were observed in 1.6% of patients.

CONCLUSIONS: The main finding of this systematic review is that modular dual mobility acetabular construct appears to be a safe and effective option for primary THA at minimum five years follow-up. Longer follow-up time is needed in order to investigate modular dual mobility long-term survivorship, revision and complication rates, clinical and radiological outcomes.

PMID:40192789 | DOI:10.1007/s00264-025-06507-2

Int Orthop. 2025 Apr 7. doi: 10.1007/s00264-025-06470-y. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to investigate the incidence and associated risk factors of ischaemic muscle sequelae in patients with traumatic femoropopliteal artery injuries following revascularization, as well as to develop a nomogram to predict the risk of ischaemic muscle sequelae.

METHODS: Data from patients with acute traumatic femoropopliteal artery injuries between January 2008 and December 2022 were collected. All patients with successful limb salvage were divided into two groups based on the occurrence of ischaemic muscle sequelae: the ischemic muscle sequelae group (IG) and the non-ischaemic muscle sequelae group (NG). Univariate and multivariate logistic regression analyses were used to identify potential predictive factors associated with ischaemic muscle sequelae. A predictive nomogram was constructed and internally validated.

RESULTS: Among the 102 patients, 30 cases (29.41%) developed ischaemic muscle sequelae. Independent predictors of ischaemic muscle sequelae were identified as crush injury, HCT, and CKMB. A nomogram was constructed based on these three parameters. The area under the receiver operating characteristic (ROC) curve of the predictive model was 0.894, indicating excellent discrimination. The calibration curve demonstrated a high degree of consistency between the predicted probabilities and the observed outcomes. Additionally, the decision curve analysis (DCA) showed that the nomogram model had good predictive capability.

CONCLUSIONS: Our study demonstrated that crush injury, HCT, and CKMB were independent predictors of ischaemic muscle sequelae in patients with acute traumatic femoropopliteal artery injuries following revascularization. The nomogram integrating clinical factors and blood markers can assist physicians in conveniently predicting the risk of ischaemic muscle sequelae in patients.

PMID:40192788 | DOI:10.1007/s00264-025-06470-y

Int Orthop. 2025 Apr 7. doi: 10.1007/s00264-025-06510-7. Online ahead of print.

ABSTRACT

PURPOSE: There is a lack of data evaluating the impact of tourniquet versus no tourniquet surgery in patients with sickle cell disease (SCD).

METHODS: The records of 233 sickle cell patients who underwent orthopaedic surgery with a tourniquet between 1978 and 2018 were retrospectively reviewed. This study group (233 patients) was compared to a control group of 574 SCD patients followed by the same surgical team in the same hospital undergoing the same procedures in the same period between 1978 and 2018 but without a tourniquet. Outcomes assessed skin complications, thrombophlebitis, bone necrosis, muscle necrosis or abnormal muscle function, peripheral nerve impairment, elevated blood pressure, post-operative sickle cell crises, and blood loss under a tourniquet.

RESULTS: The pneumatic tourniquet was primarily applied proximally in both lower and upper limbs. The median tourniquet duration was 65 minutes, with most procedures lasting between 30 and 90 minutes . Postoperative medical complications occurred in both groups, with no significant difference in hospital stay (6.7 vs. 7.1 days). Painful sickling crises affected 86 patients, with a lower prevalence in transfused patients (p = 0.04). Blood loss was significantly lower in the tourniquet group during knee surgeries (438 ml vs. 731 ml, p = 0.031), resulting in fewer transfusions. Skin complications did not affect wound healing. The 90-day incidence of venous thromboembolism (VTE) was 0.4%, with no significant difference between groups. Muscle biopsies showed no necrosis immediately post-surgery, but some necrosis appeared after 12 weeks in the tourniquet group. New bone osteonecrosis cases and infection rates were similar between groups.

CONCLUSION: this study provides valuable insights into the use of tourniquets in sickle cell disease.

PMID:40192787 | DOI:10.1007/s00264-025-06510-7

Injury. 2025 Apr 1:112313. doi: 10.1016/j.injury.2025.112313. Online ahead of print.

ABSTRACT

INTRODUCTION: Traumatic gallbladder injury has historically been associated with high morbidity and mortality. Whether treatment patterns have changed over time as non-operative management has been adopted for abdominal trauma care remains unclear. We sought to evaluate trends in cholecystectomy as a treatment for traumatic gallbladder injury and estimate the association between operative or non-operative management of traumatic gallbladder injury and patient outcomes.

METHODS: Retrospective cohort analysis of the National Trauma Data Bank from 2007-2021 evaluating patients with traumatic gallbladder injury and determining whether they received no intervention, endoscopic retrograde cholangiopancreatography (ERCP), or cholecystectomy. The probability of a patient receiving cholecystectomy or operative intervention was evaluated with an adjusted multivariable logistic regression model. To estimate the effect of intervention choice on in-hospital mortality, length of stay, and intensive care unit (ICU) length of stay, an adjusted multivariable logistic regression model was used, treating the year as a fixed effect.

RESULTS: There were 6160 traumatic gallbladder injuries recorded from 2007-2021. 3909 (63.5 %) of these patients underwent some form of intervention (drainage or cholecystectomy), including 3722 (60.4 %) undergoing cholecystectomy. The odds of cholecystectomy compared to non-operative management were decreased in several, but not all, years of study as time progressed. There was no statistically significant difference in the odds of ERCP over time. Cholecystectomy was associated with decreased odds of in-hospital mortality (aOR 0.26, 95 % CI 0.22, 0.30; p < 0.001) and 16.5 % longer length of stay (coefficient 0.15, 95 % CI 0.10-0.20; p < 0.001) compared to non-operative management.

CONCLUSIONS: Cholecystectomy use for traumatic gallbladder injury has decreased from 2007-2021 without a concurrent increase in ERCP. Patients who underwent cholecystectomy had lower odds of mortality in adjusted models. The increasing use of non-operative management for traumatic gallbladder injury may carry greater risk to patients, and operative intervention should remain the standard of care.

PMID:40189437 | DOI:10.1016/j.injury.2025.112313

Injury. 2025 Mar 24:112279. doi: 10.1016/j.injury.2025.112279. Online ahead of print.

NO ABSTRACT

PMID:40189436 | DOI:10.1016/j.injury.2025.112279

Injury. 2025 Mar 26;56(6):112290. doi: 10.1016/j.injury.2025.112290. Online ahead of print.

ABSTRACT

INTRODUCTION: The aim of the study is to describe the development of bicycle related injuries over the last four decades among young children and to describe their role as a passenger or cyclist.

METHODS: Retrospective study of 7368 children aged 0-9 years that sustained a bicycle related injury in the period 1980-2023. Incidence rates (IR) where analyzed in three age groups; 0-2 years, 3-5 years and 6-9 years. Data was analyzed in regards to age, gender, severity of injury, usage of bicycle helmet and whether the child was a cyclist or a passenger on a bike.

RESULTS: Bicycle related injury accounted for 74.5 % of all traffic related injuries for children 0-9 years treated at Odense University Hospital, Denmark 1980-2023. There was a decrease in IRs for all age groups and both genders in the study period with an overall IR decrease by 69.0 %. The IR for major and minor injury decreased for all age groups and both genders with an overall decrease of 75.6 % and 84.8 %, respectively. In the study period, 85.0 % of children were injured as cyclists and 15.0 % as passengers.

CONCLUSIONS: The study showed a significant decrease in overall IR when stratifying by age, gender, injury severity and the role of the child as cyclist or passenger. The study provides useful information for future studies and campaigns regarding children's bicycle safety.

PMID:40188610 | DOI:10.1016/j.injury.2025.112290

Injury. 2025 Mar 25;56(6):112295. doi: 10.1016/j.injury.2025.112295. Online ahead of print.

NO ABSTRACT

PMID:40188609 | DOI:10.1016/j.injury.2025.112295

Injury. 2025 Apr 5;56(6):112292. doi: 10.1016/j.injury.2025.112292. Online ahead of print.

ABSTRACT

BACKGROUND: Pulmonary contusion (PC) is considered a relative contraindication to surgical stabilization of rib fractures (SSRF). This study compared outcomes in patients undergoing SSRF vs. non-operative management (NOM).

METHODS: ACS-TQIP 2017-2020 was queried to identify patients with PC and severe chest wall injuries admitted to the intensive care unit (ICU). Outcomes included mortality, length of stay (LOS), and in-hospital complications. Subgroup analyses stratifying patients according to PC severity and institutional SSRF volume were performed. Multivariable logistic regression was used to adjust for confounders.

RESULTS: A total of 17,344 were included; 1789 (10.3 %) underwent SSRF, and 15,555 (89.7 %) did not. SSRF was associated with lower mortality (OR: 0.47, 95 % CI: 0.33-0.68, p < 0.001) but increased ventilator-associated pneumonia, tracheostomy, unplanned ICU admissions, and intubations. It was also associated with increased hospital LOS by 3.46 days (95 % CI: 2.94-3.98) and ICU LOS by 2.33 days (95 % CI: 1.99-2.68). Institutional volume above the median level of 7 SSRF cases was associated with reduced ventilator days by 1.3 days (95 % CI:2.54 to -0.05), hospital LOS by 1.7 days (95 % CI:2.58 to -0.82), and ICU LOS by 1.4 days (95 % CI:2.11 to -0.64), with no significant effects on other outcomes.

CONCLUSIONS: In patients with severe chest wall injury and PC, SSRF is associated with lower mortality at the expense of longer LOS.

PMID:40188608 | DOI:10.1016/j.injury.2025.112292

J Bone Joint Surg Am. 2025 Apr 6. doi: 10.2106/JBJS.24.00984. Online ahead of print.

ABSTRACT

BACKGROUND: Effective perioperative blood glucose control is crucial for reducing postoperative complications in patients with diabetes mellitus (DM) who are undergoing total knee arthroplasty (TKA). The aim of this study was to assess the impact of intravenous (IV) dexamethasone on blood glucose levels, insulin requirements, postoperative pain, and postoperative nausea and vomiting (PONV) in patients with well-controlled type-2 DM.

METHODS: A total of 83 Asian patients with well-controlled type-2 DM (defined as a preoperative glycated hemoglobin level of ≤7.0%) undergoing primary TKA were randomized to receive either IV dexamethasone or normal saline solution. Blood glucose and insulin requirements were monitored postoperatively up to day 5, and pain and PONV were assessed using a numeric rating scale.

RESULTS: Compared with the control, IV dexamethasone transiently elevated blood glucose levels on the day of surgery and on postoperative day 1, with the levels returning to baseline by day 3. Insulin requirements were higher in the intervention group on postoperative day 1 (p = 0.004). While IV dexamethasone did not significantly reduce PONV, it effectively alleviated postoperative pain up to day 3.

CONCLUSIONS: In patients with DM who underwent TKA, IV dexamethasone administration transiently increased blood glucose on the day of surgery and on postoperative day 1 and elevated insulin requirements on postoperative day 1. Despite having no impact on PONV, IV dexamethasone provided clinical benefits by reducing early postoperative pain. These findings suggest the potential benefits of IV dexamethasone in enhancing perioperative management strategies for patients with DM who are undergoing TKA.

LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

PMID:40188461 | DOI:10.2106/JBJS.24.00984

Injury. 2025 Mar 26;56(6):112280. doi: 10.1016/j.injury.2025.112280. Online ahead of print.

ABSTRACT

BACKGROUND: Snowboarding, skateboarding, and water surfing have emerged as popular pediatric sports. While prior work has examined differences among some types of board sports in certain populations, no prior study has directly compared pediatric injury patterns in board sports with similar techniques but on different terrains. The aim of this study was to compare the frequency and severity of orthopedic and craniofacial trauma sustained by pediatric skateboarders, snowboarders, and surfers. These injury types were selected as they encompass the majority of board sport-related trauma, providing a broad overview of injury patterns across different terrains.

HYPOTHESIS: We hypothesized that pediatric skateboarders and snowboarders sustained more fractures and strains/sprains to the upper extremity, while pediatric surfers sustained more injuries to the head and neck.

METHODS: The National Electronic Injury Surveillance System (NEISS) was queried for orthopedic and craniofacial trauma related to unpowered skateboarding, snowboarding, and surfing between 2014 and 2023. Annualized trends in injury type, injury location, and injury prevalence were examined over the study period and across sport type. Univariate analyses were utilized to compare injury characteristics and patient demographics across board sport cohorts.

RESULTS: NEISS case criteria identified an estimated 546,231 board sport injuries over the study period. Early-adolescent males were the most commonly injured cohort (76.0 %; CI: 73.8-78.2 %). Fractures to the upper extremity were the most common orthopedic injury among skateboarders (31.6 %; CI: 24.8-38.4 %) and snowboarders (45.7 %; CI: 38.9-52.5 %), while lacerations to the head and neck were the most common injury among surfers (24.5 %; CI: 22.0-26.95 %). Pediatric snowboarders sustained more upper extremity fractures and concussions, but sustained less trauma to the lower extremity.

CONCLUSIONS: Findings from this study indicate that pediatric board sport athletes sustain injuries that are analogous but unique. Upper extremity fractures are common in skateboarding and snowboarding. While surfing has a higher incidence of laceration injuries, snowboarding has a higher incidence of concussions but lower incidence of lower extremity injuries. It is important for healthcare personnel to be aware of these injury patterns, especially in settings where immediate healthcare is limited.

PMID:40187108 | DOI:10.1016/j.injury.2025.112280

Injury. 2025 Mar 17;56(6):112081. doi: 10.1016/j.injury.2024.112081. Online ahead of print.

ABSTRACT

BACKGROUND: diabetic Wound is one of the most common complications throughout the world. .This experiment was conducted in order to study the effects of vitamin k cream on repair of full thickness wound in diabetic rat.

METHODS: 75 adult Male Wistar rats were randomly divided into five groups of equal numbers; each group consists of 15 animals. After diabetes induction, full thickness wound in the shape of 2.25 CM2 square was created on the back of the rats. Group one was not treated and served as control. The woud areas in the second, third and fourth groups were covered twice a day with phenytoin (PHT) cream,0.05 and 1 % vitamin k creams, respectively. Group five treated with eucerin(vichel group) The size of wound area were measured in the 1, 4, 7, 10, 14, 18 and 21 days after wound induction. and histopathological observation and tissue parameters (hydroxyprolin(HP), collagen, glutation(GSH), malondialdeid (MDA), superoxiddesmutase(SOD), glutation peroxidase(GPX), catalase(CAT),tumor necrosis factor alpha (TNF-α), interlukin 1 bata(IL-1β)) were analysed as onther indicators of wound healing on days of 7, 14 and 21.

RESULTS: the findings indicated that PHT and 1 % vitamin k creams significantly elevated HP and collagen in contrast with control group. furthermore, in all time points, the average wound size in PHT and 1 % vitamin k groups was significantly greater than other groups (P < 0.05). Also, PHT and vitamin K 1 % creams improved oxidative and inflammatory stress parameters at all times courses. Theses findings were confirmed by histological examination.

CONCLUSION: The findings showed that 1 % vitamin k creams have potential effects on wound healing. Vitamin K exerts this effect through its antioxidant and anti-inflammatory properties, as well as stimulating collagen synthesis.

PMID:40187107 | DOI:10.1016/j.injury.2024.112081

Injury. 2025 Mar 30;56(6):112305. doi: 10.1016/j.injury.2025.112305. Online ahead of print.

ABSTRACT

BACKGROUND: Traumatic spine injury (TSI) is a prevalent condition that often requires surgical intervention. Two serious infectious complications after surgery are surgical site infections (SSI) and lower respiratory tract infections (LRTI). Yet, studies on SSI and LRTI on trauma patients, particularly with a specific focus on microbiology are lacking. The primary aim of this study is to investigate the prevalence rate of early SSI, occurring within one month of surgery or three months when instrumented, and LRTI in level-1 trauma center patients requiring surgery after TSI.

METHODS: This monocenter retrospective observational study was conducted at an academic level-1 trauma center, including patients with TSI requiring surgery. Data on patients' baseline characteristics, trauma related information, initial and intra-operative management, infectious complications data and hospitalization outcomes were collected. The two primary outcomes were the prevalence of early SSI and LRTI. Secondary outcomes included the identification of factors associated with developing these infections, analysis of identified organisms, and assessment of clinical outcomes.

RESULTS: A total of 2606 patients were screened between May 2018 and October 2022, 194 were included. Most of them were polytrauma patients defined by Injury Severity Score ≥ 16 (71 %). Early SSI occurred in 20 patients (10 %) and LRTI occurred in 58 patients (30 %). The number of vertebral levels instrumented (odds ratio [OR] 1.24, 95 % confidence interval [95 % CI] 1.01-1.52) was associated with SSI. The causative organisms were predominantly Gram-positive cocci (19/36 identified organisms). Factors associated with LRTI were an injury severity score ≥ 25 (OR 7.41; 95 % CI, 3.28-17.99), spinal injury at levels C3-C7 (OR 2.24; 95 % CI 1.01-5.14) and antibiotics during initial management (OR 7.09; 95 % CI, 2.71-20.49). The causative organisms were predominantly Gram-negative bacilli (58/80 identified organisms). Patients with LRTI experienced longer hospital stays, extended durations of mechanical ventilation, and higher mortality rates at 30 days and one year than those without.

CONCLUSION: Early SSI and LRTI are underestimated complications in severe trauma patients with TSI requiring surgery. Identifying risk factors and causative organisms is an important step for advancing research on targeted prevention and treatment of SSI and LRTI after trauma.

PMID:40187106 | DOI:10.1016/j.injury.2025.112305

Injury. 2025 Mar 25;56(6):112289. doi: 10.1016/j.injury.2025.112289. Online ahead of print.

ABSTRACT

BACKGROUND: Martial arts participation appears to be increasing in the US, and along with benefits to health and wellbeing, the sport carries musculoskeletal and neurological injury risks which differ among disciplines. Evidence is limited regarding the burden of concussion injuries in many martial arts disciplines, particularly among female athletes and outside of competitions. The purposes were: 1) to characterize injury patterns over 2013-2022 for concussion injuries treated in emergency departments (ED) related to martial arts; and 2) to compare the number of concussions by mechanism, circumstance, sex and martial art discipline.

METHODS: This was a retrospective, epidemiological study of National Electronic Injury Surveillance System (NEISS) data from patients who sought ED care for martial arts-related concussions (N = 581; 29.1 % female). Annual concussion case numbers compared over time and by sex using linear regression. Concussion case numbers were compared by major discipline (Karate, Jiu-Jitsu, Taekwondo, Mixed martial arts [MMA], kickboxing, Judo, and other forms) and sex. Mechanisms (fall, kicked, tackled/thrown, punched-hit-struck, weapon, unspecified) and circumstances (practice, competition) were compared by discipline and sex.

RESULTS: Regressions indicated that year or sex were significant contributors to annual concussion case numbers (both p>.05). The number of concussions was highest for Karate for males (p < .05). A greater proportion of cases occurred in males than females in MMA, Taekwondo, Jiu-Jitsu, and other forms (p = .031). Falls and being punched-hit-struck were the most commonly-documented mechanisms of concussion (23 % and 20 %, respectively). For females, more concussions were incurred during competition for Judo and Taekwondo than in other disciplines (p = .002). For males, more concussions occurred in class/practice with Judo and Karate than in other disciplines (p = .018). 96.4 % of cases were treated and released, and 3.1 % were hospitalized.

CONCLUSION: Since 2020, the concussion burden in martial arts has grown, particularly among males, which may be related to overall greater participation in the sport, especially karate and other forms. Prospective injury surveillance, better uptake of safety gear and implementation of skills risk into routine sport participation that minimize head injury, and careful documentation of injury circumstance could help advance martial arts safety.

PMID:40187105 | DOI:10.1016/j.injury.2025.112289

Injury. 2025 Mar 26;56(6):112283. doi: 10.1016/j.injury.2025.112283. Online ahead of print.

ABSTRACT

The meniscus, a critical load-bearing structure between the femur and the tibia, plays a key role in the functioning of the knee joint by distributing mechanical stress and minimizing friction. A brief overview of the anatomical characteristics and biomechanical functions of the meniscus is provided in this review, followed by a discussion of recent developments in tissue engineering scaffolds for meniscus repair over the past five years. The classification of scaffolds is based on the materials with an analysis of their respective advantages and limitations. The challenges associated with meniscal tissue engineering are summarized and potential research directions are proposed to guide the development of more effective regenerative strategies.

PMID:40184758 | DOI:10.1016/j.injury.2025.112283

J Bone Joint Surg Am. 2025 Apr 4. doi: 10.2106/JBJS.24.01226. Online ahead of print.

ABSTRACT

BACKGROUND: High body mass index (BMI) is a risk factor for tibial baseplate loosening following total knee arthroplasty (TKA) but may not adequately correlate with stresses at the tibial baseplate. In this study, we aimed to determine an optimal cutoff of a weight-to-tibial baseplate surface-area ratio (weight/SA) for predicting aseptic tibial baseplate loosening. We further examined whether tibial stem extensions have a protective effect.

METHODS: We identified 16,368 patients who underwent primary, elective TKA from June 2011 to March 2023. Patient demographics, including age, sex, and race, implants used, and revision surgeries were extracted. Revisions were manually reviewed to confirm revision indications. The exact surface areas of tibial baseplates were obtained from manufacturers. Receiver operating characteristic (ROC) analysis of patients without tibial stem extensions was utilized to examine the utility of BMI and weight/SA for predicting aseptic tibial baseplate loosening. Optimal weight/SA and BMI cutoffs for predicting loosening were determined. The effect of tibial stem extensions on loosening was then examined in patients at or above (n = 7,698; 3.7% with stem extension) and below (n = 8,670; 1.3% with stem extension) the determined weight/SA cutoff.

RESULTS: There were 16,368 patients in the final sample (median age, 67 years; 68.9% female; 54.1% White). Weight/SA (area under the curve [AUC] = 0.653; p < 0.001) was a better predictor of aseptic tibial baseplate loosening requiring revision compared with patient BMI (AUC = 0.624; p < 0.001). The optimal weight/SA cutoff for predicting loosening was 0.0162 kg/mm2 (sensitivity = 0.747, specificity = 0.537). Multivariable logistic regression demonstrated that being at or above the weight/SA cutoff (odds ratio [OR] = 3.17; p < 0.001) but not the BMI cutoff (p = 0.911) was a significant predictor of revision for tibial baseplate loosening in patients without stem extensions. No cases of revision for aseptic tibial baseplate loosening in patients with stem extensions occurred either at or above or below the cutoff. The rate of revision for aseptic tibial baseplate loosening in patients without stem extensions was 0.3% for patients below and 1.0% for patients at or above the weight/SA cutoff.

CONCLUSIONS: The ratio of weight-to-tibial baseplate surface area was more predictive of revision for aseptic tibial baseplate loosening following TKA compared with BMI alone. For patients with obesity with small tibial baseplate sizes, utilization of a tibial stem extension may protect against tibial loosening.

LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40184472 | DOI:10.2106/JBJS.24.01226

Int Orthop. 2025 Apr 4. doi: 10.1007/s00264-025-06513-4. Online ahead of print.

ABSTRACT

PURPOSE: This study investigated the relationship between BMI and microorganism profiles, with a particular focus on gut microorganisms in patients with PJI following total hip arthroplasty (THA). It also explored comorbidities, that may contribute to these variations.

METHODS: This study included all patients treated at our institution for a PJI of a THA between 1996 and 2021. Patients were categorized into four distinct BMI groups: <30; 30-34.9; 35-39.9; ≥ 40. Bivariate and logistic regression analysis were conducted, with presentation of odds ratio (OR) and 95% confidence interval (CI).

RESULTS: A total of 3645 hip PJI cases were recruited for the final analysis. Patients with a BMI ≥ 40 had approximately a ten fold higher risk for Streptococcus dysgalactiae (p < 0.001; OR = 9.92; 95% CI 3.87-25.44) and a seven fold higher risk for Proteus mirabilis (p < 0.001; OR = 7.43; 95% CI 3.13-17.67) and Klebsiella pneumoniae (p < 0.001; OR = 6.9; 95% CI 2.47-19.31). Furthermore, polymicrobial infections (p < 0.001; OR = 2.17; 95% CI 1.50-3.15) were found to be significantly more prevalent in patients with a BMI ≥ 40.

CONCLUSION: Obese patients (BMI ≥ 30) displayed a distinct microorganism profile in hip PJIs, mainly dominated by Firmicutes and Proteobacteria. Comorbidities such as diabetes, hypertension, and hyperlipidaemia may contribute to a leaky gut syndrome, increasing PJI risk caused by gut microorganisms. Optimizing comorbidities may help reduce the risk of hip PJI. Further research is needed to clarify the relationship between obesity, gut microbiome alterations and hip PJI development.

PMID:40183945 | DOI:10.1007/s00264-025-06513-4

J Bone Joint Surg Am. 2025 Apr 3. doi: 10.2106/JBJS.24.00224. Online ahead of print.

ABSTRACT

BACKGROUND: Directed growth modulation is commonly utilized as a surgical treatment for early-onset scoliosis. Growing rods are instrumented on the spine and apply sustained tension on the immature spine for a substantial amount of time, with the clinical goal of accommodating axial expansion of the spine. Despite the use of growing rods in humans, the mechanobiology of the spinal tissues under tensile loading remains relatively unknown. To bridge this knowledge gap, we developed a preclinical mouse model that allows for mechanistic investigations of sustained tension on the spine.

METHODS: Using custom 3D-printed washers and tunable springs, we distracted across the seventh and ninth caudal vertebrae of adolescent and young adult C57BL/6 female mice with forces that were approximately 2 times the body mass of the animal. The springs were replaced weekly to maintain tension for the duration of the experiment. A set of 6-week-old animals were first instrumented for 10 weeks to evaluate the feasibility and tolerability. Subsequently, the 6- and 12-week-old experimental animals were instrumented until they were 20 weeks of age in order to evaluate the effects of tension until adulthood. The spines were monitored using digital radiography and micro-computed tomography (µCT), and the intervertebral discs (IVDs) were evaluated using mechanical testing and compositional assays.

RESULTS: The device was well tolerated and caused no notable complications. The tensile forces lengthened the vertebrae in the 6-week-old animals that were instrumented for 14 weeks and in the 12-week-old animals that were instrumented for 8 weeks. Increased IVD heights were observed in the 6-week-old animals but not in the 12-week-old animals. The porosity of the vertebral end plates increased following instrumentation in all groups but progressively recovered over time.

CONCLUSIONS: Distraction accelerated the lengthening of the vertebrae and the heightening of the IVD, with no observable degeneration or decline in the mechanical performance of the IVDs for these distraction conditions.

CLINICAL RELEVANCE: This model will be useful for investigating how spinal tissues adapt to directed growth modulation with maturation and aging.

PMID:40179155 | DOI:10.2106/JBJS.24.00224