Prehospital erythrocyte transfusion: a clinical overview of aeromedical care in a Southern Brazilian macro-regional health system
Injury. 2026 Jan 22:113058. doi: 10.1016/j.injury.2026.113058. Online ahead of print.
ABSTRACT
INTRODUCTION: Prehospital erythrocyte transfusion, well-established in the management of hemorrhagic shock in developed countries, was incorporated into trauma care in Brazil in 2022, representing a significant advance in the treatment of severe trauma. This study aimed to describe the clinical profile of patients with severe trauma who received prehospital erythrocyte transfusion by the SAMU aeromedical team in a health macro-region in Southern Brazil.
METHODS: This retrospective cross-sectional study (2022-2024) included patients with severe trauma treated by a regional SAMU aeromedical team who received prehospital erythrocyte transfusion at the trauma scene. Clinical, laboratory, and hemodynamic variables were collected, including prehospital and hospital shock index values. The primary outcome was 24-hour mortality. Associations with early mortality were explored using Fisher's exact test with exact odds ratios. Changes in shock index between prehospital and hospital moments were evaluated with the Wilcoxon signed-rank test, while differences between survivors and non-survivors were assessed with the Mann-Whitney test.
RESULTS: Results: Thirty-eight patients were included, and 10 (26%) died within 24 hours. Prehospital erythrocyte transfusion was associated with a significant reduction in shock index, decreasing from a median of 1.85 (IQR 1.53-2.40) at the scene to 1.15 (IQR 0.90-1.68) on hospital arrival (p < 0.001), with no difference in the magnitude of reduction between survivors and non-survivors (p = 0.38). Non-survivors presented a more unfavorable metabolic profile on admission, with lower base excess and hematocrit and higher lactate levels. Older age (≥60 years) and a positive FAST showed higher odds of early mortality (OR 5.2 and 5.8, respectively), although both associations had wide confidence intervals and two-sided Fisher p-values of 0.06. All seven patients who experienced cardiac arrest at the scene died within 24 hours. No transfusion-related adverse events were recorded; however, key physiological parameters such as ionized calcium and core temperature were not systematically monitored.
CONCLUSION: Prehospital erythrocyte transfusion was feasible within this aeromedical service and was associated with early improvement in shock index. Although no transfusion-related adverse events were recorded, incomplete physiological monitoring limits definitive conclusions regarding safety. These findings support the potential role of prehospital transfusion as a supportive measure in severe trauma, particularly in aeromedical settings.
PMID:41582035 | DOI:10.1016/j.injury.2026.113058












